Protection against Advanced Glycation End products (PAGE) by Frontier International

One of the most deleterious effects of 'normal' ageing is rising glucose (blood sugar) levels. Excess glucose flood cells throughout the body, overwhelming their metabolic machinery and increasing the mitochondrial production of free radicals. Failure to conrtrol this excess sugar can lead to numerous health issues.

Benfotiamine, a fat-soluble form of Vitamin B1 (Thiamine) supports healthy blood sugar metabolism and acts through several mechanisms to block the biochemical pathways by which high sugar creates havoc throughout the body. e.g. the enzymes trasnkelotase is critical to blood sugar metabolism like many enzymes, however transkelotase requires a cofactor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water soluble, which makes it less available to the interior of the cell. Since benfotiamine is fat soluble, it enters areas of the body where water soluble thiamine cannot penetrate.

Many studies confirmed that benfotiamine increased transketolase activity in cell cultures by astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage. Benfotiamine also blocks the activation of the transcription factor known as nuclear factor - kappa beta (NF-KB), which are implicated in numerous inflammatory conditions.

Frontier's PAGE, enriched with Benfotiamine (250mg), Vitamin B1 (Thiamine) (50mg), Vitamin B6 (1mg), Vitamin B12 (1.5mcg), Body Guard (TM) (1g), is a low cost dietary supplement that can help maintain already normal sugar levels and support the health of the nerves, kidneys, eyes, blood vessels and heart.


Primary Benefits:

Vitamin B1 (Thiamine)
A water soluble vitamin which helps the body cells convert carbohydrates into energy. It is also essential for the functioning of the heart, nervous system and digestive system. It plays an important role in stopping the formation of Advanced Glycation End products (AGE).

Benfotiamine
A fat soluble vitamin, it is the cousin of Thiamine. It blocks destructive pathways that enable high blood sugar levels to damage nerves and small blood vessels. It inhibits the formation of AGE. It is also essentiial in boosting the function of Thiamine in our body cells.

Vitamin B6
A water soluble vitamin. It is involved in the production and digestion of amino acids. The vitamin helps to manufacture the hormone insulin, antibodies that fight infection and certain chemicals that send messages between nerve cells. It also plays a key role in the production of haemoglobin and in the ability of oxygen to bind with the haemoglobin molecule. It is a very important transporter for Thiamine and Benfotiamine.

Vitamin B12
A water soluble vitamin. It is needed for the synthesis of red blood cells, the proper functioning of the nervous system, manufacturing DNA and the processing of fats and carbohydrate. It plays an important role as a transporter of Thiamine and Benfotiamine.

Body Guard (TM)
Body Guard has blood glucose-lowering effects in diabetic patients which include increased tissue glucose uptake. liver and muscle glycogen synthesis, inhibition of enzymes involved in glucose production and enhanced glucose oxidation.It also prevents the leading of diabetes complication such as neuropathy, retinopathy and kidney damage.

What Makes this product unique?
THIAMIN, as a water-soluble vitamin, has an upper dose limit approach in which additional quantities are simply secreted in urine. Clearly, for the beneficial anti-AGE effects and related reduction in inflammatory markers to be realised, a better means of delivering thiamine to tissues is needed. Fortunately, thiamine's fat soluble cousin, BENFOTIAMINE is a highly bioavailable nutrient that has unique structure that can pass directly through cell membranes which achieves better absorption and distribution throughout the body. Benfotiamine can reach tissues more than 5 times more readily than thiamine.

Who should take this product?
PAGE is suitable for anyone from infant to pregnant women. It is highly recommended for strict vegetarians who have insufficient vitamin B complex from their diet.

Other related postings:
1. DIABETES UNLEASHES A CASCADE OF DEBILITATING HEALTH COMPLICATIONS
2. EUROPEAN SUPPLEMENT PROTECT AGAINST DIABETIC COMPLICATIONSDirectionOne sachet a day. Mix with room temperature water or any other nutritious drink. Maximum dosage is 5 sachets per day.