EUROPEAN SUPPLEMENT PROTECTS AGAINST DEABETIC COMPLICATIONS

When treating diabetes, today's doctors focus on establishing blood glucose control, but often overlook the need to protect against common diabetic complications such as blindness, stroke, endothelial dysfunction, and loss of limb.

Fortunately, benfotiamine, a little known fat soluble form of vitamin B1, has been shown to help prevent the development and progression of many diabetic complications. As a result, benfotiamine has become a critical nutrient for those seeking to ward off the potentially lethal impact of sustained high blood sugar levels.

Used for decades in Europe as a prescription medication, benfotiamine ameliorates the progression of diabetic nerve, kidney, and retinal damage, and relieves the painful symptoms of diabetic neuropathy. Diabetic neuropathy makes it difficult for nerves to carry messages to the brain and also impairs the function of the microvasculature (tiny blood vessels) in the extremities.The result of this pathological blood-vessel damage is numbness and painful tingling in the feet (and hands) that can eventually result in amputation of the lower extremities.

Benfotiamine acts through a novel mechanism, blocking the biochemical pathways by which high blood sugar damages cells throughout the body. Now available as a low-cost dietary supplement, benfotiamine can help diabetes sufferers protect their nerves, kidneys, eyes, blood vessels, and heart. Benfotiamine's multifaceted effects in preventing dangerous diabetic complications make it an essential supplement for people with elevated blood sugar levels.

Article by Dale Kiefer.

Related postings:
1. "Diabetic Unleashes a Cascade of Debilitating Health Complications"
2. Protection against Advanced Glycation End products (PAGE) by Frontier International

DIABETES UNLEASHES A CASCADE OF DEBILITATING HEALTH COMPLICATIONS

Diabetes is one of today's most challenging health afflictions, owing to its explosive growth, devastating effects on the body, and the difficulty of effectively treating the disease and its complications.

In a healthy person, food is converted into glucose, which is subsequently absorbed into the bloodstream. In response to this increase in plasma glucose, the pancreas secretes the hormone insulin, which shepherds glucose molecules into the body's cells, where they are stored or burned for energy.

In pre-diabetic and diabetic individuals, however, the cells resist insulin and the entry of glucose into the cells. When this happens, specialised cells in the pancrease known as islet cells respond by pumping out more insulin. Over time, the islet cells burn out altogether. The result is hyperglycemia, or high blood sugar, rendering the patient utterly dependent on a constant supply of pharmaceutical insulin.

Despite these challenges, most cells maintain relatively normal concentrations of internal glucose. However, certain cells - most ntably endothelial cells, which line the interior of arteries and capillaries - are less capable of self-regulation. They tend to accumulate high levels of internal glucose, which they cannot metabolise efficiently. This causes intermediate glucose breakdown products to pile up, activating metabolic pathways that are implicated in the onset of diabetic complications.

Especially in the small blood vessels that feed the eys, kidneys and extrremities, the toxic intermediates of glucose breakdown leave a wake of damage. For example, in the retina, this dysfunctional glucose metabolism may lead to blindness. In the kidneys, it may cause irreversible tissue damage, eventually leading to kidney failure. And in the extremities, it may cause vascular disease and nerve pain, possibly requiring amputation.

This article is written by Dale Kiefer, "European Supplement Protects Against Diabetic Complications".

Other related postings:
1. Protection against Advanced Glycation End products (PAGE) by Frontier International
2. European Supplement Protect Against Diabetic Complications

Protection against Advanced Glycation End products (PAGE) by Frontier International

One of the most deleterious effects of 'normal' ageing is rising glucose (blood sugar) levels. Excess glucose flood cells throughout the body, overwhelming their metabolic machinery and increasing the mitochondrial production of free radicals. Failure to conrtrol this excess sugar can lead to numerous health issues.

Benfotiamine, a fat-soluble form of Vitamin B1 (Thiamine) supports healthy blood sugar metabolism and acts through several mechanisms to block the biochemical pathways by which high sugar creates havoc throughout the body. e.g. the enzymes trasnkelotase is critical to blood sugar metabolism like many enzymes, however transkelotase requires a cofactor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water soluble, which makes it less available to the interior of the cell. Since benfotiamine is fat soluble, it enters areas of the body where water soluble thiamine cannot penetrate.

Many studies confirmed that benfotiamine increased transketolase activity in cell cultures by astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage. Benfotiamine also blocks the activation of the transcription factor known as nuclear factor - kappa beta (NF-KB), which are implicated in numerous inflammatory conditions.

Frontier's PAGE, enriched with Benfotiamine (250mg), Vitamin B1 (Thiamine) (50mg), Vitamin B6 (1mg), Vitamin B12 (1.5mcg), Body Guard (TM) (1g), is a low cost dietary supplement that can help maintain already normal sugar levels and support the health of the nerves, kidneys, eyes, blood vessels and heart.


Primary Benefits:

Vitamin B1 (Thiamine)
A water soluble vitamin which helps the body cells convert carbohydrates into energy. It is also essential for the functioning of the heart, nervous system and digestive system. It plays an important role in stopping the formation of Advanced Glycation End products (AGE).

Benfotiamine
A fat soluble vitamin, it is the cousin of Thiamine. It blocks destructive pathways that enable high blood sugar levels to damage nerves and small blood vessels. It inhibits the formation of AGE. It is also essentiial in boosting the function of Thiamine in our body cells.

Vitamin B6
A water soluble vitamin. It is involved in the production and digestion of amino acids. The vitamin helps to manufacture the hormone insulin, antibodies that fight infection and certain chemicals that send messages between nerve cells. It also plays a key role in the production of haemoglobin and in the ability of oxygen to bind with the haemoglobin molecule. It is a very important transporter for Thiamine and Benfotiamine.

Vitamin B12
A water soluble vitamin. It is needed for the synthesis of red blood cells, the proper functioning of the nervous system, manufacturing DNA and the processing of fats and carbohydrate. It plays an important role as a transporter of Thiamine and Benfotiamine.

Body Guard (TM)
Body Guard has blood glucose-lowering effects in diabetic patients which include increased tissue glucose uptake. liver and muscle glycogen synthesis, inhibition of enzymes involved in glucose production and enhanced glucose oxidation.It also prevents the leading of diabetes complication such as neuropathy, retinopathy and kidney damage.

What Makes this product unique?
THIAMIN, as a water-soluble vitamin, has an upper dose limit approach in which additional quantities are simply secreted in urine. Clearly, for the beneficial anti-AGE effects and related reduction in inflammatory markers to be realised, a better means of delivering thiamine to tissues is needed. Fortunately, thiamine's fat soluble cousin, BENFOTIAMINE is a highly bioavailable nutrient that has unique structure that can pass directly through cell membranes which achieves better absorption and distribution throughout the body. Benfotiamine can reach tissues more than 5 times more readily than thiamine.

Who should take this product?
PAGE is suitable for anyone from infant to pregnant women. It is highly recommended for strict vegetarians who have insufficient vitamin B complex from their diet.

Other related postings:
1. DIABETES UNLEASHES A CASCADE OF DEBILITATING HEALTH COMPLICATIONS
2. EUROPEAN SUPPLEMENT PROTECT AGAINST DIABETIC COMPLICATIONSDirectionOne sachet a day. Mix with room temperature water or any other nutritious drink. Maximum dosage is 5 sachets per day.